LONDON, May 23, 2019 /PRNewswire/ — Leading international Trade Fairs wire and Tube sponsor the first

LONDON, May 23, 2019 /PRNewswire/ — Leading international Trade Fairs wire and Tube sponsor the first CRU Conference in Johannesburg in November 2019 The African continent is full of economic challenges. Especially Africa’s enormous oil and gas reserves, its numerous copper mines, large aluminium deposits and expanding regional steel industry have moved the continent into the focus of international investors more than ever before. Ambitious infrastructure projects fuel the local economy which, in turn, seeks foreign know-how for implementing these measures. International manufacturers of machinery and equipment for the wire and cable industries and the producers of tube making and finishing machines are therefore highly sought-after partners for industry. Wires, cables and tubes are required in mining and the energy sector and in infrastructure.  Reason enough for Messe Düsseldorf, the organiser of the world’s biggest trade fair for wire, cable and tube – wire and Tube – to take part as a sponsor in the Africa Wire, Cable & Tube Conference held for the first time by the British organiser CRU in cooperation with AHK, the German Chamber of Industry and Comme...

Conflict arises with San Lorenzo Valley Water District budget-cutting plans

BOULDER CREEK — Tensions ran high Wednesday as San Lorenzo Valley Water District managers told board directors that a budget scenario spending 5% less on operations than the previous fiscal year was not achievable. District budgeting plans for the fiscal year beginning July 1 have already come under public scrutiny for proposed spending reductions in environmental monitoring, conservation and education program areas, even prior to a scenario that cut operational spending to lower than last year’s approximately $8 million. The total proposed budget, with capital improvement costs, is about $17.3 million. During Wednesday’s special meeting to discuss the latest draft of the budget, the board agreed to further reduce spending in that area with the elimination of an $88,000 water conservation specialist position. In a budget report to the board, district staff said it could bring operational spending down nearly to last year’s levels with some difficult decisions but the district would come up against a wall of relatively fixed expenses if it went any further. “The desire for a 5% reduction would require layoffs, or folding up departments as a whole, along with other expense reducti...

SwitchArcade Round-Up: ‘Mortal Kombat 11’, ‘SEGA AGES Puyo Puyo’ Details, ‘Travis Strikes Again’, More New Releases, Today’s Sales, and More

Hello gentle readers, and welcome to the SwitchArcade Round-Up for January 18th, 2019. Today we’ve got a big blow-out of Mortal Kombat 11 footage, some new information on the SEGA AGES release of Puyo Puyo, today’s new releases, a handful of sales, and a few other things. Maybe a Megazord will show up? Who knows! Let’s morph into the article! I’ll cop to it: I’m not a huge fan of Mortal Kombat these days. I was fascinated by the first game, played the second game obsessively with my friends in high school, and more or less checked out after that. I’d dip in every few games to see if the old magic would come back, and yeah, still not my thing. But this is one of the most popular fighting game franchises in the world, so the new game is huge news by any definition. That it’s coming to Switch alongside other platforms only makes it more exciting. WB Games did a big blowout yesterday, showing off some story info and a bunch of gameplay footage including some of the new fatalities. It probably goes without saying, but this footage isn’t from the Switch version. But yeah, it looks like a Mortal Kombat game. Don’t watch the video at work or you’ll probably get in trouble. From develope...

New machines and equipment shouldn’t be the first place to look for increasing efficiency and performance.

New machines and equipment shouldn’t be the first place to look for increasing efficiency and performance. At a time when warehouse managers are expected to move more product at a faster pace and at a lower cost, efficiency is key. Updating decades-old material handling equipment may seem like a way to boost operations, but experts say there are many things warehouse operators may be able to do to make better use of their existing machinery. Implementing a modern warehouse management system (WMS) is the first step to opening a new door for data to drive new efficiencies. Internet of Things (IoT) devices and sensors can also offer new visibility into how to improve processes and configurations, and enabling predictive maintenance to help machinery to perform better. Finally, conveyor systems can be upgraded from tubes to slat-carrying surfaces to better accommodate the growth of e-commerce and new packaging. While warehouse machinery has improved dramatically in recent years, new machines and equipment shouldn’t be the first place to look for increasing efficiency and performance. Warehouse operators can attain many productivity gains without major capital expenditur...

Types of B vitamins: Functions, sources, and deficiencies

For full functionality, it is necessary to enable JavaScript. Here are instructions how to enable JavaScript in your web browser. Healthline Media, Inc. would like to process and share personal data (e.g., mobile ad id) and data about your use of our site (e.g., content interests) with our third party partners (see a current list) using cookies and similar automatic collection tools in order to a) personalize content and/or offers on our site or other sites, b) communicate with you upon request, and/or c) for additional reasons upon notice and, when applicable, with your consent. Healthline Media, Inc. is based in and operates this site from the United States. Any data you provide will be primarily stored and processed in the United States, pursuant to the laws of the United States, which may provide lesser privacy protections than European Economic Area countries. By clicking “accept” below, you acknowledge and grant your consent for these activities unless and until you withdraw your consent using our rights request form. Learn more in our Privacy Policy. We use cookies and similar technologies to improve your browsing experience, personalize content and offers, show targeted...

OGF Article Static Equipment: A Look Inside the ‘How and Why’ of Specification

The majority of mechanical equipment found in oil and gas facilities belongs to the static equipment group, which comprises pressure vessels (drums, columns, reactors, filters) and heat exchangers (shell and tubes, plate and frame, air coolers). The presented guidelines contain cost-effective recommendations for their design, materials, and fabrication. They aim to enable the project engineer, who is not an equipment specialist, to check that economical choices are made. The specification and selection of the equipment is the responsibility of the static equipment engineer, based on requirements specified by other disciplines, including process, materials and plant layout. These other disciplines are not always aware of the impact of their demands on the cost/lead time of the equipment. Conversely, the static equipment discipline is not always aware of where the requirements of these disciplines come from and if the onerous ones could be challenged. Such interface data are the focus of this article, which aims to give a cross-discipline awareness. Site conditions (wind, seismic, blast; or reference to the project document containing such information, e.g., basic engineering desi...

Multi-effect evaporator Market by Major Players, Development, Opportunities, Market Driving Forces & Forecast 2024

The Multi-effect evaporator market report provides a unique, first-time market and competitive analysis of the size, segmentation, competition, trends and outlook in the manufacture and supply of Multi-effect evaporator in the world. Besides, the report also identifies and analyses the emerging trends along with major drivers, challenges and opportunities in the Multi-effect evaporator market. Request for Sample Copy of Multi-effect evaporator Market Report at https://www.pioneerreports.com/request-sample/8582 Chapter One Introduction of Multi-effect evaporator Industry 1.1 Brief Introduction of Multi-effect evaporator 1.2 Development of Multi-effect evaporator Industry 1.3 Status of Multi-effect evaporator Industry Chapter Two Manufacturing Technology of Multi-effect evaporator 2.1 Development of Multi-effect evaporator Manufacturing Technology 2.2 Analysis of Multi-effect evaporator Manufacturing Technology 2.3 Trends of Multi-effect evaporator Manufacturing Technology Chapter Three Analysis of Global Key Manufacturers 3.1 Company A 3.1.1 Company Profile 3.1.2 Product Information 3.1.3 2014-2019 Production Information 3.1.4 Contact Information 3.2 Company B 3.2.1 Company Profi...

Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells

The Wnt/β-catenin (β-cat) pathway plays a critical role in cancer. Using hydrocarbon-stapled peptide technologies, we aim to develop potent, selective inhibitors targeting this pathway by disrupting the interaction of β-cat with its coactivators B-cell lymphoma 9 (BCL9) and B-cell lymphoma 9-like (B9L). We identified a set of peptides, including hsBCL9CT-24, that robustly inhibits the activity of β-cat and suppresses cancer cell growth. In animal models, these peptides exhibit potent anti-tumor effects, favorable pharmacokinetic profiles, and minimal toxicities. Markedly, these peptides promote intratumoral infiltration of cytotoxic T cells by reducing regulatory T cells (Treg) and increasing dendritic cells (DCs), therefore sensitizing cancer cells to PD-1 inhibitors. Given the strong correlation between Treg infiltration and APC mutation in colorectal cancers, it indicates our peptides can reactivate anti-cancer immune response suppressed by the oncogenic Wnt pathway. In summary, we report a promising strategy for cancer therapy by pharmacological inhibition of the Wnt/β-cat signaling. Numerous studies have implicated the canonical Wnt pathway, a tightly regulated signal trans...

We tested more than 50 cordless drills and we didn’t ignore the wallet-friendly brands. The best

We tested more than 50 cordless drills and we didn’t ignore the wallet-friendly brands. The best budget cordless drill is different depending on whether you’re doing occasional projects around the house or if you’re a value-minded Pro. Here are our picks for the cordless drills that won’t break the bank! SUPPORT OUR ADVERTISERS googletag.cmd.push(function() { googletag.display(‘div-gpt-ad-1389975325257-0′); }); The essence of the best budget cordless drill for DIYers focuses on an easy-to-swallow price and easy-to-use size without losing the ability to do the job well. Skil’s compact DL529301 embodies that beautifully with a user-friendly design. It does all that with a trade-off in performance. It performs all of the tasks we asked of it without an issue, just slower. If you’re looking for something that gets closer to Pro performance, look to the bigger drills. When you’re targeting a do-anything drill driver that nearly anyone can comfortably use, this is a great one to have in your home. Ryobi’s P252 brushless drill driver goes after the same general design characteristics but is narrowly behind Skil in every category except value. That makes it a worthy (and clo...

Probably ever since the beginning of growing crops for food some 10,000 years ago, farmers have

Probably ever since the beginning of growing crops for food some 10,000 years ago, farmers have been battling hungry insects. Sulphur, mercury and arsenic were used by ancient Chinese, while Romans and Greeks tried religious and folk magic rituals and smelly smoke from burning stinky objects such as fish and dung. Then, maybe 2,000 years ago, the Persians discovered that a powder, Pyrethrum, made from grinding the dried blooms of a species of Chrysanthemum flower would protect stored grain from insect damage. Bordeaux mixture (lime and copper sulfate), sodium arsenate, creosote, and nicotine derivatives, such as Black Leaf 40 which my parents used in our large garden, were prevalent in this country. After World War II, chlordane, DDT, and other very effective chemicals were developed and widely used until they were found to be unsafe for humans and other animals and most were banned. Today, insect control is safer and more sophisticated, even to the point of genetically engineered crops that are boll weevil and corn borer resistant. However, the growing demand for “organically grown” food has revived interest in the ancient Persian pesticide pyrethrum. Pyrethrum is organic, has...

Linux-driven i.MX ULL board drives $99 touch-panel kit

YPE html PUBLIC “-//W3C//DTD XHTML 1.0 Transitional//EN” “http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd”> MYIR’s new “MYD-Y6ULX-HMI” dev board, built on a previous iMX6 ULL module, also drives a new $99 “MYD-Y6ULX-CHMI” 7-inch touch-panel display kit with a pre-installed Linux HMI stack and optional wireless add-on. MYIR has launched a $59 and up development board built around its MYC-Y6ULX computer-on-module, which runs Linux on NXP’s power-sipping i.MX6 ULL SoC. The MYD-Y6ULX-HMI dev board powers a new 7-inch capacitive touch-panel display called the MYD-Y6ULX-CHMI. The kit features a pre-installed Linux HMI stack and offers an optional MYB-Y6ULX-HMI-4GEXP IO wireless add-on board. The 130 x 88mm MYD-Y6ULX-HMI differs from the standard dev board in that it has fewer ports, but adds 4-wire resistive and capacitive touch interfaces. Both are location on the back of the board where the 16-bit LCD interface has been repositioned. All the wireless interfaces and the second Fast Ethernet found on the standard dev board have moved to an optional, $35 “MYB-Y6ULX-HMI-4GEXP IO Board,” which connects to the board via dual 20-pin heade...

‘The Hills’ Made Reality TV What It Is. Now It’s Back.

Kaitlynn Carter Jenner, Mischa Barton and Jennifer Delgado filming a scene for “The Hills: New Beginnings” in December.CreditCreditIlona Szwarc for The New York Times It was a sleepy Tuesday in Santa Barbara, just before the new year, when a bunch of people who were once on a popular reality show swept into town. Their first stop was a winery nearby. They walked in, and then they walked out, and then they walked in again. Then they fought like children over whose seat was whose. “I was always sitting here,” said Stephanie Pratt, the sister of the show’s villain, Spencer Pratt. “Are you crazy?” said Justin (Bobby) Brescia, a former hairstylist for the band Maroon 5 and the show’s toxic bachelor. “You’re sitting here.” At a table some 50 yards away, Lauren Weber, the showrunner of “The Hills: New Beginnings,” was listening on a headset and sighing. Though she had instructed the cast where to sit, she did not expect them to ruin the shot by discussing it on camera. “O.K., have her do it again, since she boned this entire shot — on the arrival,” she said, speaking with the lilt of a reluctant babysitter. And so they walked in a third time. Then they took a break. “Can everyone go p...

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